Widespread Adoption of Precision Anticancer Therapies After Implementation of Pathologist-Directed Comprehensive Genomic Profiling Across a Large US Health System
SOPHiA GENETICS Launches MSK-IMPACT® powered with SOPHiA DDM™. This solution provides organizations worldwide with the opportunity to benefit from Memorial Sloan Kettering Cancer Center (MSK)’s best-in-class comprehensive genomic profiling (CGP) application on the SOPHiA DDM™ Platform with high accuracy and efficiency.
**Shifting the Paradigm in Whole-Genome Sequencing for Newborns Interview with Dr. Wendy Chung, a clinical and molecular geneticist and Chief of the Department of Pediatrics at Boston Children’s Hospital and Harvard Medical School, discussing the importance of advancing newborn screening with whole genome sequencing, and how healthcare providers can advocate for this important advancement.
Flatiron to offer Tempus AI’s testing through OncoEMR platform

(Omics) Data Platform / Sequencing / Analysis / Instruments

Tagomics Announces a Multiomic Profiling Co-Marketing Agreement with Agilent
**Oxford Nanopore and UK Biobank to create world’s first epigenetic dataset targeting the causes of cancer, dementia, complex disease The initiative will map the epigenome using 50,000 samples with the goal of advancing early disease detection, diagnosis and treatment in cancer, neurological disease and other common complex diseases
DNAnexus Wins BioTech Breakthrough Award for BioInformatics Solution of the Year
TileDB Powers Multiomics Research: Now Trusted by Half of Top Global Pharma Giants
Whole Genome MRD Detection with One-in-a-Million LOD: Inocras Launches WGS-Based, Panel-Free MRDVision, Leveraging Ultima ppmSeq^TM Technology
Complete Genomics announces mpox virus amplicon sequencing panel
GenomOncology and Genomenon Partner to Enhance Germline Variant Classification and Genomic Reporting

Genomic / Genetic Testing / CDx

Artificial Intelligence / Machine Learning / LLM / ChatGPT / GenAI

**Leading the era of AI changes, Insilico Medicine is proudly listed in fortune 50 AI innovators Other honorees include internet giants like Alibaba, ByteDance, Meta, and Microsoft; leading companies in the chip industry such as AMD and NVIDIA; and AI emerging stars like Hugging Face and OpenAI.
Dante Genomics to Launch Generative AI Features in Dante Labs Whole Genome Platform
Sanofi, Formation and OpenAI design AI tool to slash clinical trial timelines
Regulating generative AI: FDA’s challenges laid bare by digital health advisory committee The Food and Drug Administration commissioner Robert Califf began a marathon meeting on regulation of generative artificial intelligence with an urgent warning. He said clinicians around the country had told him the technology’s adoption in their hospitals and clinics was being driven by financial considerations — not patient care.

Metagenomics

Delve Bio Presents Data Showing Metagenomic Next-Generation Sequencing (mNGS) Delivers Greater Diagnostic Yield Than Conventional Methods in Central Nervous System Infections
**1 Genomic Test Can Diagnose Nearly Any Infection Next-generation metagenomic sequencing test developed at UCSF proves its effectiveness in quickly diagnosing almost any kind of pathogen.

CRISPR/Genome Editing

New Gene-Editing Tool Targets Mutations with Unmatched Precision A new tool called Helicase-Assisted Continuous Editing (HACE) allows scientists to create precise genetic mutations in specific genes without affecting the rest of the genome.

Miscellaneous

Eli Lilly drug cuts genetic form of cholesterol by 86%: Study
Revvity Broadens Relationship with Genomics England to Advance Genomics in the UK
Fitness Level May Offset Genetic Dementia Risk U.K. Biobank data suggests that genetic risk for Alzheimer’s disease and dementia appeared to be partly offset by high levels of cardiorespiratory fitness.
iSpecimen Releases Cancer Biospecimen Offering; Orders Anticipated of Over $9,500,000 Annually
Takara Bio Launches High-Throughput, Cost-Effective qPCR System to Advance Clinical Research
How health care could change under the new Trump administration
**23andMe cuts 40% of its workforce, discontinues all therapy programs
Epic advances interoperability standards
**Genetic Discrimination Is Coming for Us All
WHO releases handbook for digital transformation in primary care
Trump names Dr. Mehmet Oz to head Centers for Medicare and Medicaid Services
23andMe inks new research partnership as it winds down internal drug development efforts 23andMe has notched a research partnership with Mirador Therapeutics to provide the biotech company with access to its trove of genetic data

Publications

**Nature Publishes Collection of Papers Advancing the Human Cell Atlas, With Research Supported by CZI – See Nature: The Human Cell Atlas: towards a first draft atlas In a collection of research articles and related content, the Human Cell Atlas consortium presents tools, data and ideas towards the generation of their first draft atlas of cells in the human body.
Digital profiling of gene expression from histology images with linearized attention
**Long-read DNA and RNA Sequencing, a Special Collection by Genome Research. This special issue (Volume 34, Number 11) highlights advances in long-read sequencing applications in biology and medicine.
**Cell therapy fights lethal childhood brain cancer in Stanford Medicine trial Read the article Intravenous and intracranial GD2-CAR T cells for H3K27M⁺ diffuse midline gliomas
Researchers discover a new metabolic compound that regulates body weight Read the full article: A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites
**A panoramic view of cell population dynamics in mammalian aging
Seemingly “Broken” Genes in Coronaviruses May be Essential for Viral Survival
**Deep generative AI models analyzing circulating orphan non-coding RNAs enable detection of early-stage lung cancer
The Parkinson’s disease drug entacapone disrupts gut microbiome homeostasis via iron sequestration Study reveals that the widely prescribed Parkinson’s disease drug entacapone significantly disrupts the human gut microbiome by inducing iron deficiency. This study provides new insights into the often-overlooked impact of human-targeted drugs on the microbial communities that play a critical role in human health.
Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition
Deciphering the genetic interplay between depression and dysmenorrhea: a Mendelian randomization study
Engineered receptors for soluble cellular communication and disease sensing
Variation in human gut microbiota impacts tamoxifen pharmacokinetics
**The commitment of the human cell atlas to humanity The Human Cell Atlas pioneers a global effort to map human biology and bridge health inequities with cutting-edge genomics. The study highlighted HCA’s framework of inclusivity, transparency, and global cooperation and suggested that it could serve as a model for other large-scale scientific endeavors. HCA’s approach mirrors the principles of past projects like the Human Genome Project and the 1000 Genomes Project, emphasizing open data access and ethical research practices.
**Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy Study reveals new genetic explanation for dilated cardiomyopathy. For the study, the research teams worked with collaborators from around the world to collect and analyse the results of 16 existing studies alongside new data, comparing the genomes of 14,256 people who had dilated cardiomyopathy with more than a million people who did not have the disease.
The emergence of Sox and POU transcription factors predates the origins of animal stem cells
**Seven-year performance of a clinical metagenomic next-generation sequencing test for diagnosis of central nervous system infections Metagenomic sequencing improves detection of rare pathogens in CNS infections
A blueprint for better cancer immunotherapies By examining antigen architectures, MIT researchers built a therapeutic cancer vaccine that may improve tumor response to immune checkpoint blockade treatments.
Key Pathway Leading to Neurodegeneration in Early Stages of ALS Identified Read the full article: Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes
Leveraging ancient DNA to uncover signals of natural selection in Europe lost due to admixture or drift

News for the month of October 2024

Funding & IPO

Mergers & Acquisitions

Precision Medicine

Rapid Blood Cancer Diagnostic Could Speed Decisions and Save Lives Researchers at Dana-Farber Cancer Institute have created a CRISPR-based rapid molecular diagnostic for two forms of leukemia that are driven by mutations that involve gene fusions. The technology accurately detects the presence of these gene fusions in acute promyelocytic leukemia (APL) and chronic myeloid leukemia (CML) in patient samples.
Sanofi commits $18 million to Howard University College of Medicine, Meharry Medical College, and Morehouse School of Medicine to increase diversity in clinical studies

(Omics) Data Platform / Sequencing / Analysis / Instruments

Genomic / Genetic Testing / CDx

Pharmacogenetics (PGx)

Genomind Launches First-of-Its-Kind Patient Report: Offering Patients an Easy-to-Understand View into Personalized Genetic Test Results

Laboratory Management/Informatics Platforms

RWD / RWE

Tempus Announces Collaboration with JW Pharmaceutical to Apply Real-World Data and Biological Modeling to Enhance Early Research and Development

Artificial Intelligence / Machine Learning / LLM / ChatGPT

Miscellaneous

**Discovery in Tiny Worm Leads to Nobel Prize in Physiology or Medicine for 2 Scientists The prize was awarded to Victor Ambros and Gary Ruvkun for their discovery of microRNA, which helps determine how cells develop and function.
**Nobel Prize in Chemistry Goes to 3 Scientists for Predicting and Creating Proteins The laureates are: Demis Hassabis and John Jumper of Google DeepMind, who used A.I. to predict the structure of millions of proteins; and David Baker of the University of Washington, who used computer software to invent a new protein.
**Nobel Physics Prize Awarded for Pioneering A.I. Research by 2 Scientists With work on machine learning that uses artificial neural networks, John J. Hopfield and Geoffrey E. Hinton “showed a completely new way for us to use computers,” the committee said.
Scientists create first map of DNA modification in the developing human brain Findings could help pinpoint cell types most vulnerable to conditions like schizophrenia, autism spectrum disorder. The data resource has been made publicly available through an online platform.
A new method makes high-resolution imaging more accessible Labs that can’t afford expensive super-resolution microscopes could use a new expansion technique to image nanoscale structures inside cells.
Oura Ring Data Reveals New Insights into Perimenopause
HLTH24: Jill Biden announces $110M ARPA-H funding award, prods industry to invest in women’s health
Why hundreds of US pharmacies are closing
New DiMe platform validates digital health software
Cleveland Clinic, Amazon’s One Medical partner
Nvidia, Google, Microsoft and more head to Las Vegas to tout health-care AI tools
Two Scientists Win March of Dimes Basil O’Connor Grants to Advance Artificial Womb for Preterm Babies, Sickle Cell Screening for Newborns in Sub-Saharan Africa
Maven Clinic Valued At $1.7 Billion, A Growth Signal For Women’s Health
**The US obesity rate fell in 2023 – We may have passed peak obesity We have known for several years from clinical trials that Ozempic, Wegovy and the new generation of diabetes and weight loss drugs produce large and sustained reductions in body weight. Now with mass public usage taking off — one in eight US adults have used the drugs, with 6 per cent current users — the results may be showing up at the population level.
Flatiron Health Surpasses 1,000 Research Publications Using High-Quality Real-World Data From Its De-Identified Patient Database

Publications

Gene-based burden tests of rare germline variants identify six cancer susceptibility genes Study identifies new cancer susceptibility genes in germline genetic variation study
**Comprehensive genome analysis and variant detection at scale using DRAGEN Illumina’s DRAGEN outperforms current state-of-the-art methods (Google DeepVariant, Broad GATK) in speed and accuracy
**Rare variant contribution to the heritability of coronary artery disease Study shows that ultra-rare gene variants drive coronary artery disease risk in European ancestry
Baby boomers living longer, but in poorer health than previous generations
A web portal for exploring kinase-substrate interactions New web portal empowers drug discovery, systems-level analysis of critical kinase-substrate interactions
Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes

News for the month of September 2024

Funding & IPO

Nomic® Secures $42M in Oversubscribed Series B to Expand Access to Protein Profiling
NIH awards $27M to establish new network of genomics-enabled learning health systems The new Genomics-enabled Learning Health System (gLHS) Network aims to identify and advance approaches for integrating genomic information into existing learning health systems. As genomic testing becomes increasingly common, more and more genomic data are available in clinical settings, and learning health systems present an opportunity to translate this evidence quickly and directly into improvements in medical care.
Cercle Secures $6M Seed Funding to Expand AI-Driven Women’s Healthcare Platform Cercle, an AI company, wants to transform women’s healthcare data into actionable insights,
Viome Raises $25M To Launch Diagnostic Division and Bring On Former Amazon SVP and Samsung Chief Digital Officer, Kal Raman, as Chief Operating Officer
Segmed, a startup that gathers medical imaging data for AI development, raises $10M
Radiant Bio Closes $35 Million Series A Financing to Advance Therapeutic Pipeline with Its Proprietary Multabody™ Platform
Eli Lilly jumps deeper into AI with $409M Genetic Leap deal Eli Lilly has vaulted into an AI-enabled drug discovery deal, partnering with RNA specialist Genetic Leap in a pact worth up to $409 million in upfront and milestone payments.

Mergers & Acquisitions

**Illumina wins Grail battle in blow to EU merger power The annulment has important knock-on effects for Illumina: the EC’s record €432 million fine on Illumina for implementing the transaction without prior EC approval (and symbolic fine of €1,000 on Grail—the first time a gun-jumping fine was levied against a target company) now falls away, and Illumina’s challenge to the EC’s prohibition of the deal is moot. The ECJ’s ruling is final.

Precision Medicine

Nanostics and Protean BioDiagnostics Partner to Launch CDX Prostate for Men at Risk of Having Aggressive Prostate Cancer in the United States
UK’s first robotic genomic testing facility for cancer patients launches
SOPHiA GENETICS Unveils New Generation of the SOPHiA DDM™ The new-gen SOPHiA DDM™ Platform offers a new architecture designed to more efficiently compute large amounts of data at-scale, while elevating customer experience with integrated access to multimodal analytics modules.

Genomic / Genetic Testing / CDx

**Remember That DNA You Gave 23andMe? The company is in trouble, and anyone who has spit into one of the company’s test tubes should be concerned – a critical article by the Atlantic (Kristin Brown)
MGI Tech partners with Dasa to enhance health diagnosis with genetic sequencing in Brazil
Natera Announces Three New Signatera Publications; Includes Overall Survival Data Published in Nature Medicine
Uptake of Cancer Genetic Services for Chatbot vs Standard-of-Care Delivery Models

(Omics) Data Platform / Sequencing / Analysis / Instruments

Velsera Technology Paves the Way for Advanced Cancer Diagnostics with FDA Approval of Illumina TruSight™ Oncology Comprehensive IVD Velsera’s tumor profiling technology is now a key part of Illumina’s TruSight ™ Oncology Comprehensive IVD, recently approved by the FDA
ONTOFORCE unveils DISQOVER 7: the next generation knowledge discovery platform
Let the Nanopore Wars begin: BGI has a new nanopore sequencer A blog post by Brian Krueger discussing how BGI just fired the first salvo in what is sure to be an exciting conflict between BGI and Nanopore
MGI Launches New Nanopore Sequencing Products with Advanced CycloneSEQ Technology CycloneSEQ™ technology integrates numerous technological improvements, including advanced protein engineering, a novel flow cell design, and a cutting-edge base calling algorithm, to enable high accuracy and throughput in sequencing.

Spatial Genomics / Single Cell Genomics

Integrity Solution to Measure Whole Genome Copy Number Variation in Advanced Therapies and Tumor Samples

Data Platforms / Laboratory Management Systems

Protein Metrics Launches New Multi-Protein Quantitation Workflows for Biopharmaceutical Proteomics Researchers Protein Metrics is part of the Dotmatics business of scientific R&D software
Ganymede Bio Launches Industry-First GxP-Native Developer Platform and Data Infrastructure for Wet Lab Data

Artificial Intelligence / Machine Learning / LLM / ChatGPT

**The revolution in high-throughput proteomics and AI
Roche advances AI-driven cancer diagnostics by expanding its digital pathology open environment Roche announced the expansion of its digital pathology open environment with the integration of more than 20 advanced artificial intelligence (AI) algorithms from eight new collaborators. These strategic collaborations aim to support pathologists and scientists in cancer research and diagnosis by leveraging cutting-edge AI technology.

RWD / RWE

Amy Abernethy teams with former Verily exec to improve data-driven clinical research by launching Highlander Health Highlander Health aims to optimize clinical trials by integrating research more seamlessly into day-to-day care to improve treatments and enable individualized patient care.
Tempus Announces Expansion of Collaboration with Takeda to Leverage Multimodal Real-World Datasets and Biological Model Systems in Oncology Research and Development

Miscellaneous

Apple pitches sleep apnea detection, OTC hearing aid features
Weight-loss market to see 16 new drugs by 2029, report estimates
Amazon inks digital health partnership with Talkspace, adds mental health provider to health conditions program
Roche Narrows Pharma Pipeline Amid Push Into Obesity Market The company cut about 25% of its pipeline, said Teresa Graham, chief of Roche’s pharma division
**23andMe CEO Anne Wojcicki ‘surprised and disappointed’ by board resignations All seven independent directors resigned from 23andMe’s board – CEO Anne Wojcicki said she was “surprised and disappointed by the decision.”
Digital Twins of Biological Systems Inform Drug Development
Ozempic, Wegovy, Rybelsus: Are we losing sight of overall health? Here’s what the science says The clinical effectiveness of GLP-1/GIP analogs in reducing the complications associated with Type 2 diabetes and obesity is indisputable. However, these drugs are not suitable for everyone, and they are certainly not miracle cures that will make it possible for one to regain health without making any changes to lifestyle or environment.
Fobeni Healthcom launches innovative natural GLP-1 drink
**How do drugs like Ozempic work? And why are they on trial?

Publications

Blindfolding DeepVariant: Surprising Insights from Hiding Information Blog investigates the importance of various features of sequencing data to the ability to accurately call variants.
**Highly accurate assembly polishing with DeepPolisher Study presents PHARAOH (Phasing Reads in Areas Of Homozygosity), which uses ultra-long ONT data to ensure alignments are accurately phased and correctly introduce heterozygous edits in falsely homozygous regions. They demonstrate that the DeepPolisher pipeline can reduce assembly errors by half, with a greater than 70% reduction in indel errors. They have applied our DeepPolisher-based pipeline to 180 assemblies from the next Human Pangenome Reference Consortium (HPRC) data release, producing an average predicted Quality Value (QV) improvement of 3.4 (54% error reduction) for the majority of the genome.
Picture imperfect – Scores of papers by Eliezer Masliah, prominent neuroscientist and top NIH official, fall under suspicion
Benchmarking whole exome sequencing in the German network for personalized medicine A research group from the German Network for Personalized Medicine (DNPM) has recorded the quality standards according to which genome analyses are carried out in Germany.
**The 1% gift to humanity: The Human Genome Project II Scientists are calling for human genomic research to be vastly expanded and widened to include many more people so it can fully deliver on its promise of becoming a tool for improved health care for all of humanity.
Integration of variant annotations using deep set networks boosts rare variant association testing Study demonstrates how DeepRVAT enables calibrated and computationally efficient rare variant tests at biobank scale, aiding the discovery of genetic risk factors for human disease traits.
Phenome-wide Mendelian randomisation analysis of 378,142 cases reveals risk factors for eight common cancers Researchers have examined thousands of genetically defined traits to identify possible causal relationships for eight common cancers. The team evaluated data from more than 860,000 people to uncover potential factors in causing breast, bowel, endometrial, lung, esophageal, ovarian, prostate and kidney cancers.
Enhancing the Polygenic Score Catalog with tools for score calculation and ancestry normalization Study present a series of recent enhancements to the PGS Catalog and highlight the PGS Catalog Calculator, an open-source, scalable and portable pipeline for reproducibly calculating PGSs that democratizes equitable PGS applications.
Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset
**Observational and genetic evidence disagree on the association between loneliness and risk of multiple diseases Loneliness has been associated with serious adverse clinical outcomes. A new UK Biobank report, using Mendelian randomization, shows most of this is not causal, but attributable to co-morbidities and other risk factors.
Insidious chromatin change with a propensity to exhaust intestinal stem cells during aging
Deep learning based decoding of single local field potential events AI reveals new insights into human brain activity
Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis Study reveals how aging immune system fuels cancer growth, potentially opening new avenues for prevention – preclinical model suggests blocking inflammation pathways may reverse cancer-promoting effects of aging, inspiring early-phase clinical drug trials
Alternating high-fat diet enhances atherosclerosis by neutrophil reprogramming
Continuous multiplexed phage genome editing using recombitrons
**DNA may be a powerful predictor of educational success, new research suggests The researchers point to the findings of their new study, which reveal that recent advances in DNA analysis mean we now know genetics are one of the strongest predictors of how far an individual will go in education and the grades they will achieve.
An artificial intelligence accelerated virtual screening platform for drug discovery
Global impact of unproductive splicing on human gene expression Study suggests that alternative splicing may have an even greater influence on biology than just by creating new protein isoforms. The biggest impact of alternative splicing may come via its role in regulating gene expression levels.
Do people reach 100 by surviving, delaying, or avoiding diseases? A life course comparison of centenarians and non-centenarians from the same birth cohorts

News for the month of August 2024

Funding & IPO

PhotonPharma Secures $2.5 Million in Seed Funding to Advance Clinical Trial for Ovarian Cancer Treatment
Talus Bioscience Announces $11.2M in New Funding Led by Two Bear Capital to Advance AI Platform for Transcription Factor Therapeutic Discovery
**Human Longevity, Inc. Completes an Upsized $39.8M Series B Financing to Expand its Precision 100+ Longevity Care Program
Clarium Secures $10.5M for AI-Powered Hospital Supply Chain
Jade Biosciences Launches with $80 Million to Develop Transformative Therapies for Autoimmune Diseases
£28.5m in funding for Human Functional Genomics Initiative Funding will support functional genomics research across the UK and contribute to the establishment of a new functional genomics screening laboratory.
Biotech financing: darkest before the dawn After a difficult three years, biotech financing may slowly be returning to health.
Novo Holdings Invests £50M in Oxford Nanopore
**23andMe board rejects CEO Wojcicki’s take-private proposal

Mergers & Acquisitions

**Danaher Acquires Swiss Informatics Firm Genedata Genedata’s offerings are expected to add to Danaher’s broad workflow solutions that help accelerate the speed of drug discovery, development, and manufacturing for critical new therapies. Over the past several years Genedata and Danaher have engaged in several successful collaborations.
Biotech firm Recursion to buy smaller peer Exscientia for $688 million
Roche considering sale of cancer data startup Flatiron Health Pharmaceutical giant Roche bought health tech startup Flatiron Health for $1.9 billion in 2018 to expand its reach into real-world evidence and accelerate its development of cancer medicines.
n2 Group Expands with the Acquisition of Life Sciences and Healthcare Computing Consultancy BioTeam

Precision Medicine

(Omics) Data Platform / Sequencing / Analysis / Instruments

Micro-costing of genetic diagnostics in acute leukemia in Sweden: from standard-of-care to whole-genome sequencing Study insights reveal the evolving landscape of whole-genome sequencing for acute leukemias. The cost of whole-genome sequencing is poised to align with current routine analysis methods within a year. The study highlights reagent costs as the primary expense, with potential for a 50% decrease, bringing whole-genome sequencing closer to routine analysis costs.
The calculations performed in this study clearly show that by utilizing the capacity of the new sequencing instruments is how reagent costs are likely to decrease by 50%.
Dovetail Genomics and Goenomics GmbH Announce Strategic Partnership to Enhance Genome Annotation Services Under this partnership, Goenomics will provide advanced annotation services, significantly improving the speed and expanding the portfolio of Dovetail’s genome annotation offerings. Leveraging Goenomics’ newly developed, proprietary algorithm for homology-based gene reconstruction, this partnership will ensure that researchers receive reliable and comprehensive annotation results.

Spatial Omics / Single-cell Genomics

Mission Bio’s Tapestri Platform Utilized for Advancements in Gene-Edited T-Cell Therapy

CRISPR / Genome Editing

Editing fetal genomes is on the horizon—why ethical discussions with target communities should happen now

Laboratory/Scientific Management Systems

Miscellaneous

Epic touts new AI applications to streamline charting and bring research insights to the point of care The goal is to ease the documentation burden for clinicians, streamline charting and coding and bring evidence-based medical insights and research right to doctors’ fingertips at the point of care.
**Walgreens Lands $100 Million U.S. Clinical Trials Partnership Walgreens said it has signed a partnership with the U.S. government valued at $100 million for the drugstore giant to conduct clinical trials to aid in future emergency preparedness.
Bristol Myers Squibb Receives U.S. Food and Drug Administration sBLA Acceptance for First-Line Treatment of Unresectable Hepatocellular Carcinoma
**Genentech to shut down cancer immunology research department amid broader R&D rethink Genentech will close its cancer immunology research department, and unit head and renowned cell biologist Ira Mellman, who has been with the company for 17 years, will depart in the coming months. The company’s cancer immunology research function will be merged with molecular oncology research, which is currently led by Frederic de Sauvage, to form one single cancer research body within Genentech Research and Early Development (gRED),
US FDA clears use of Cresilon’s gel to stop severe bleeding in seconds
**23andMe Board Committee ‘Disappointed’ in CEO Anne Wojcicki’s Take-Private Proposal
1 in 5 US Abortions Are Now Through Telehealth
Epic rolls out new feature to make it easier for patients to share medical records with health apps
Medicare finalizes reimbursement rule for breakthrough medical devices
**23andMe Cuts Back Drug Research, Moves to Weight Loss

Artificial Intelligence / Machine Learning / ChatGPT

BiomedGPT: A Versatile Transformer-Based Foundation Model for Biomedical AI with Enhanced Multimodal Capabilities and Performance BiomedGPT is an open-source, lightweight vision–language foundation model designed for various biomedical tasks.
OmniScreen by Paige: An AI Tool that Simultaneously Screens 505 Genes for Comprehensive Cancer Diagnosis and More Personalized Treatments OmniScreen is an AI-driven biomarker module capable of evaluating over 505 genes and detecting 1,228 molecular biomarkers from routine H&E-stained digital pathology slides.

Publications

**Homozygosity for a stop-gain variant in CCDC201 causes primary ovarian insufficiency Scientists at deCODE genetics and collaborators, have identified a sequence variant in the CCDC201 gene that when inherited from both parents homozygous causes menopause on average nine years earlier. By analyzing data from over 174,000 women across Iceland, Denmark, the UK, and Norway, the researchers discovered a stop gain variant leading to a change from and Arginine at position 162 to Termination in the CCDC201 gene, that dramatically impacts AOM. Women carrying two copies of this variant, referred to as homozygotes, experience menopause an average of nine years earlier than non-carriers
**A deep learning method that identifies cellular heterogeneity using nanoscale nuclear features Artificial intelligence differentiates cancer cells and detects early viral infections. The tool, AINU (AI of the NUcleus), scans high-resolution images of cells. The images are obtained with a special microscopy technique called STORM, which creates a picture that captures many finer details than what regular microscopes can see. The high-definition snapshots reveal structures at nanoscale resolution.
Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes The findings of the 12-year observational study provide a clearer picture of the genetic changes that may be important in each subtype of this cancer of our antibody producing plasma cells, which is treatable but incurable.
Pan-pathogen deep sequencing of nosocomial bacterial pathogens in Italy in spring 2020: a prospective cohort study Researchers have developed a new genomic technique that can track the spread of multiple superbugs in a hospital simultaneously, which could help prevent and manage common hospital infections quicker and more effectively than ever before. This study captured the whole population of pathogenic bacteria found in multiple hospital intensive care units (ICUs) and ordinary wards during the first wave of the 2020 COVID-19 pandemic. Researchers could see the type of bacteria patients had, including any well-known antibiotic-resistant pathogens found in hospitals.
**Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules A computational model built by researchers at the Institute of Research in Biomedicine (IRB Barcelona) and the Centre for Genomic Regulation (CRG) can predict which drugs will be most effective in treating diseases caused by mutations that can bring protein synthesis to a halt, resulting in unfinished proteins.
Relevance of Mediterranean diet as a nutritional strategy in diminishing COVID-19 risk: A systematic review
**Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations This study involved a diverse dataset of 5,306 participants from 15 countries, including participants from the US, Latin America (LAC), Europe, and Asia. The study found that structural socioeconomic inequality, air pollution, and the burden of communicable and non-communicable diseases were significant predictors of increased brain age gaps, especially in more disadvantaged countries. The research also highlighted sex differences in brain aging, with women in LAC countries showing greater brain age gaps, particularly in those with Alzheimer’s disease. These differences were linked to biological sex and gender disparities in health and social conditions. These findings underscore the role of environmental and social exposomes in brain health disparities.
Investigating Genetic Overlap between Alzheimer’s Disease, Lipids, and Coronary Artery Disease: A Large-Scale Genome-Wide Cross Trait Analysis Study systematically evaluated the genetic overlap between Alzheimer’s disease (AD), lipid profiles, and coronary artery disease (CAD) traits using large-scale genetic data and robust analytical methods – reveals genetic link between Alzheimer’s disease, lipid metabolism, and coronary artery disease
Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry
Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes The findings of the 12-year observational study provide a clearer picture of the genetic changes that may be important in each subtype of this cancer of our antibody producing plasma cells, which is treatable but incurable. This information could help guide more personalized treatments in the future.
Assessing a single-cell multi-omic analytic platform to characterize ex vivo-engineered T-cell therapy products Showcases the Tapestri single-cell multiomic assay for the analytical characterization and safety assessment of an ex vivo T-cell therapy
Nonlinear dynamics of multi-omics profiles during human aging This research demonstrates that functions and risks of aging-related diseases change nonlinearly across the human lifespan and provides insights into the molecular and biological pathways involved in these changes. The analysis revealed consistent nonlinear patterns in molecular markers of aging, with substantial dysregulation occurring at two major periods occurring at approximately 44 years and 60 years of chronological age.
Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming

News for the month of July 2024

Funding & IPO

Foresight Diagnostics Expands Series B Financing to $73.75 Million to Advance the Foresight CLARITY™ MRD Platform
**Spear Bio Raises $45M in Series A Financing Protein-Based Diagnostics Using qPCR Instruments
**Element Biosciences Raises Over $277 Million to Develop and Commercialize Differentiated Products and Continue Rapid Growth
NOWDiagnostics Secures $22.5 Million in Series B Funding
Spotlight Medical Secures €6.2M in Seed Funding to Enhance Cancer Treatment Strategies with AI-Powered Prognosis Tests
Predicta Biosciences Secures $5.2M to Transform the Diagnosis, Treatment and Monitoring of Blood Cancers
Ancilia Biosciences Announces Closing of $4.2 Million Financing Ancilia Biosciences harnesses the natural power of CRISPR to create bacterial therapies and products with immunity against destructive viruses
Truvian Health Raises $74M to Bring Blood Testing to Anyone, Anywhere
Parker Institute Commits Additional $125M for Audacious Mission to Cure Cancer
Third Arc Bio Launches with Oversubscribed $165 Million Series A Financing to Deliver Superior Biologics for Solid Tumors and Inflammatory & Immunology (I&I) Diseases
Clarapath Closes $36M B Round to Transform 150-year old Laboratory Processes a medical robotics company modernizing and transforming how pathology laboratories process tissue
RetiSpec Closes $10M USD to Advance Commercialization of its AI-Driven Eye Test for Detection of Alzheimer’s Disease
Scopio Labs Secures $42 Million in Funding Led by Fortissimo Capital
Rejuvenate Bio Receives $4M in Funding from the California Institute for Regenerative Medicine (CIRM)
Danish start-up Kvantify secures EUR 10 million seed round to unlock quantum computing potential, starting with life sciences

Mergers & Acquisitions

Boehringer Ingelheim Acquires Nerio Therapeutics
**Agilent to acquire contract development and manufacturing organization (CDMO) BioVectra for nearly $1 billion
**Illumina acquires Fluent BioSciences to accelerate single-cell analysis and discovery to a broader customer base The Fluent team will join Illumina, and PIPseq V will be integrated into Illumina’s product portfolio. The company plans to build on Fluent’s technology to develop full end-to-end solutions for single-cell analysis.
**Thermo Fisher Scientific has completed its acquisition of Olink, a provider of next-generation proteomics solutions.The transaction values Olink at approximately $3.1 billion, net of $96 million of acquired cash. Olink will become part of Thermo Fisher’s Life Sciences Solutions segment.

Precision Medicine

Guardant Health’s Shield Blood Test Approved by the FDA as a Primary Screening Option for Colorectal Cancer
Qiagen to cut 175 employees, close Michigan PCR test plant
Quest Diagnostics is closing its facility and is laying off more than 100 people
FDA approves blood test to screen for colon cancer
**FinnGen Selects Azenta to Propel Personalized Medicine for Population Health Study The FinnGen project is a pioneering endeavor that has collected and is currently analyzing genomic and health data from a cohort of 500,000 Finnish biobank participants.

(Omics) Data Platform / Sequencing / Analysis / Instruments

Genomic / Genetic Testing / CDx

Labcorp Expands Collaboration with Ultima Genomics to Advance Whole Genome Sequencing Applications and Oncology Testing Capabilities
3X4 Genetics and Cenegenics Announce Partnership to Revolutionize Personalized Health and Wellness Combining innovative science with a deep understanding of the aging process, 3X4 Genetics aligns perfectly with Cenegenics’ mission by integrating advanced genetic testing into its health assessment and wellness programs.
MGI Tech and Predica Diagnostics Team Up for Precision RNA Sequencing in Oncology MGI collaborates with Predica Diagnostics, a leading innovator in oncology diagnostics, to develop Predica’s targeted RNA sequencing tests on the cost-effective MGI Next-generation sequencing platforms.

Artificial Intelligence / Machine Learning / ChatGPT

**Insilico releases AI-powered hardware platform, PandaOmics Box for on-premise drug discovery and personalized medicine research To facilitate maximum data privacy and data security, Insilico Medicine (“Insilico”), developed a hardware platform, PandaOmics Box, that does not require Internet access and allows for on-premise biological analytics, target identification, biomarker discovery, indication prioritization and advanced research in personalized medicine and drug discovery. The PandaOmics Box is a seamless integration of Insilico’s proprietary generative biology AI software PandaOmics,
Biostate AI Emerges from Stealth and Launches Total RNA Sequencing and Free Data Analysis AI Launches two service products: Total RNA sequencing and Copilot for RNAseq data analysis.
**Insilico Medicine’s PandaOmics Box enhances drug discovery with advanced AI capabilities The PandaOmics Box is a seamless integration of Insilico’s proprietary generative biology AI software PandaOmics, extensive scientific database, and advanced hardware system with state-of-the-art computational power and chip-level confidential computing. Designed for on-premise deployment, the PandaOmics Box allows the product to operate efficiently in a completely offline mode, therefore provides a secure environment for privacy data analysis.

Miscellaneous

Revvity Q2 Revenues Drop 2 Percent on Softer Life Sciences Sales Tempered by Dx Growth
**Ozempic’s biggest side effect: Turning Denmark into a ‘pharmastate’?
**23andMe Reaches Agreement in Principle to Settle Class Action Data Breach Lawsuit 23andMe has reached an agreement in principle to settle a class action lawsuit that was filed in response to a breach of customer data in 2023. The breach occurred in October 2023 and resulted in the theft of the data of approximately 6.9 million individuals, around half of its customers. There was no breach of 23andMe’s systems, instead a threat actor conducted a credential stuffing attack, which allowed access to be gained to certain customer accounts. Around 14,000 individual accounts were compromised, around 0.1% of its customers.
**Guardant Health hit with $900K-plus kickback settlement
Roche Weighs In With Encouraging Early Clinical Data for Oral GLP-1 Drug
BeiGene Opens Flagship U.S. Biologics Manufacturing and Clinical R&D Facility in New Jersey – Continues Global Expansion $800 million investment in New Jersey supports global growth and expansion with technologically advanced manufacturing capacity and clinical development capabilities for novel cancer medicines
Bristol Myers Squibb Receives European Medicines Agency Validation of Application for Opdivo (nivolumab) plus Yervoy (ipilimumab) for First-Line Treatment of Unresectable or Advanced Hepatocellular Carcinoma
Illumina Ventures Adds Two New Experts as Advisors Adding Dr. Timothy Stenzel and Jerry Steiner join as Advisors
biomodal Files Patent Infringement Lawsuit Against New England Biolabs
**Roche sues Stanford University, cancer-detection startup Forsight Diagnostics over trade secrets Roche said in the that Stanford University professors Maximilian Diehn and Ash Alizadeh, whose technology Roche acquired in 2015, secretly created Foresight while working as Roche consultants and stole its technology to use in their new business.

Publications

**Circular RNA in cancer New study published in Nature Reviews Cancer, predicts remarkable potential for circular RNAs to improve cancer treatment and patient outcomes within the next 5–10 years.
**Spatial molecular profiling of mixed invasive ductal and lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations
Long-term risk of autoimmune diseases after mRNA-based SARS-CoV2 vaccination in a Korean, nationwide, population-based cohort study
Explainable drug repurposing via path based knowledge graph completion
Microproteins Found in Tumors Could Lead to Cancer Vaccines
Hundreds of new genome sequences fill gaps in the fruit fly tree of life
Discovery of antimicrobial peptides in the global microbiome with machine learning
Postacute Sequelae of SARS-CoV-2 Infection in the Pre-Delta, Delta, and Omicron Eras Study shows that vaccination credited for 70% reduction in long COVID risk over course of pandemic
Sources of gene expression variation in a globally diverse human cohort Study addresses a long-standing diversity bias in human genetics
**New genetic tool could identify drug targets for diseases associated with metabolic dysfunction This interactive app, called GenMAP, allows queries for the associations linking genes with blood metabolites
Multiplex cerebrospinal fluid proteomics identifies biomarkers for diagnosis and prediction of Alzheimer’s disease Study ueses multiplex proteomics for the simultaneous measurement of multiple proteins within a sample
**Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program This large-scale genome-wide association study (GWAS) using data from the United States Department of Veterans Affairs (VA) Million Veterans Program (MVP) – one of the largest US-based biobanks – fills crucial gaps in our knowledge of the relationships between genes, traits, and disease across diverse populations, according to a new study.
Exome Sequencing Identifies Carriers of the Autosomal Dominant Cancer Predisposition Disorders Beyond Current Practice Guideline Recommendations Researchers at the Mayo Clinic Center for Individualized Medicine Tapestry project sequenced the exomes and identified 550 people, or 1.24%, as carriers of the hereditary mutations.
** Benefits for children with suspected cancer from routine whole-genome sequencing This study is the first time that the impact of using whole genome sequencing in current NHS practice has been assessed.
eQTLs identify regulatory networks and drivers of variation in the individual response to sepsis

News for the month of June 2024

Funding and IPO

Precision Medicine

(Omics) Data Platform / Sequencing / Analysis / Instruments

MGI Tech and SeqOne Partner to Advance End-to-end Genomic Analysis SeqOne provides AI-driven genomic decision support software, to develop and validate end-to-end genomic analysis solutions from sample to report tailored to the needs of Human Genetics and Pathology labs worldwide.

Artificial Intelligence / Machine Learning / ChatGPT

**OpenAI Expands Healthcare Push With Color Health’s Cancer Copilot Color Health has developed an AI assistant using OpenAI’s GPT-4o model to help doctors screen and treat cancer patients
**FDA joins international push for transparency in AI development The FDA is joining hands with regulators in Canada and the U.K. on policies to ensure transparency in the development of medical devices powered by machine learning.
**PicnicHealth Announces PicnicAI, a Platform that Unlocks the Universal Patient Record with Generative AI PicnicAI collects medical records from everywhere in the U.S. and transforms them into meaningful data for patients and researchers. It is powered by a proprietary, industry-leading LLM that outperforms GPT-4 and healthcare industry-specific models in accuracy, efficiency, and cost on tasks that involve structuring or understanding medical records.
IPA’s Subsidiary BioStrand and PGxAI Announce Strategic Collaboration to Develop First-In-Class AI Model for Pharmacogenomics Recommendations Using LENS^ai™

Spatial Omics / Single-cell Genomics

Mission Bio Announces Launch of First Single-Cell Multiple Myeloma Multiomics Solution Aimed to Transform Translational Research and Therapy Development

CRISPR/Genome Editing

A New CRISPR-Driven Technology for Gene Drive in Plants

Miscellaneous

Publications

**Retraction Note: Microbiome analyses of blood and tissues suggest cancer diagnostic approach
Metabolic inflexibility promotes mitochondrial health during liver regeneration
AAV gene therapy for hereditary spastic paraplegia type 50: a phase 1 trial in a single patient
In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer STudy finds that people who have mutations in these genes are more likely to develop fast-growing tumors—but these tumors are also more susceptible to chemotherapy.
Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations Researchers from the Schulich School of Medicine & Dentistry and the University of California San Diego (UCSD) used genetic data as well as self-reported coffee-consumption numbers to assemble a genome-wide association study (GWAS). The researchers compared coffee-consumption genetic characteristics from a 23andMe database in the U.S. with an even larger set of records in the United Kingdom.
Retrieval-Augmented Generation–Enabled GPT-4 for Clinical Trial Screening This study assessed the accuracy and cost of a Gen AI process they named RAG-Enabled Clinical Trial Infrastructure for Inclusion Exclusion Review (RECTIFIER), that identifies patients who meet criteria for enrollment in a heart failure trial based on their medical records.
**Exome sequence analysis identifies rare coding variants associated with a machine learning-based marker for coronary artery disease Using an advanced artificial intelligence tool, researchers at the Icahn School of Medicine at Mount Sinai have identified rare coding variants in 17 genes that shed light on the molecular basis of coronary artery disease (CAD), the leading cause of morbidity and mortality worldwide.
New technique reveals how gene transcription is coordinated in cells By capturing short-lived RNA molecules, scientists can map relationships between genes and the regulatory elements that control them.

News for the month of May 2024

Funding & IPO

Opmed.ai Secures $15M to Bring AI Optimization to Healthcare Operation
Tempus AI Files for US IPO Touting ‘Intelligent Diagnostics’
Rad AI, a startup that helps radiologists save time on report generation, raises $50M Series B from Khosla Ventures
Sibel Health Receives $17.5M Grant from the Gates Foundation to Advance Maternal Health Monitoring
Phenomix Sciences Raises $7.8M to Acclerate Obesity Precision Medicine Adoption
Atropos Health lands $33M to scale AI-powered real-world evidence, build out pharma partnerships
YGION Biomedical announces €15 Million Series A Financing to develop Individualized Cancer Immunotherapies
Matter Bio Successfully Closes $7M Seed Funding Round
Zenas adds $200M series C to reach a bucket of key readouts for lead monoclonal antibody
Flagship Pioneering Unveils Prologue Medicines to Unlock the Therapeutic Potential of the Viral Proteome Flagship has initially committed $50 million to advance the company’s Decoding Evolutionary Logic of Variant Ensembles (DELVE)™ Platform to develop a pipeline of medicines for a wide range of diseases, with an initial focus in immunological, oncology and metabolic indications
BridgeBio taps VCs for $200M, fueling oncology spinout’s push to surpass KRAS class
Delphia Therapeutics Completes $67M Series A and Launches to Pioneer a New Field of Cancer Medicines: Activation Lethali
Karius Raises $100M Co-Led by Khosla Ventures, 5AM Ventures and Gilde Healthcare, to Expand Access to Advanced Genomic Diagnostics in Infectious Disease, Addressing Antimicrobial Resistance Crisis

Precision Medicine

Oxford Nanopore Technologies Collaborates With Twist Bioscience to Launch Pharmacogenomics Beta Programme and Advance Personalised Medicine
Foundation Medicine and PMV Pharma Announce Collaboration to Develop Companion Diagnostic for Rezatapopt, a First-In-Class, Investigational, Selective p53 Y220C Reactivator
Bristol Myers Squibb’s CAR T Cell Therapy Breyanzi Approved by the U.S. Food and Drug Administration for Relapsed or Refractory Follicular Lymphoma
FDNA and Genome Medical Improve Access to Critical Diagnostic Services for Children in Medically Underserved Areas
SOPHiA GENETICS to Launch New Whole Genome Sequencing Capabilities They are collaborating with Microsoft and NVIDIA to leverage their expertise in technology and genomics to bring a streamlined and scalable whole genome sequencing (WGS) analytical solution to healthcare institutions
The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan
OM1 Launches Three New Products Powered by Patented AI Platform to Expedite Delivery of Personalized Medicine

(Omics) Data Platform / Sequencing / Analysis / Instruments

Complete Genomics expands to East Coast with new Customer Experience Center in Greater Boston’s Biotech Hub
Complete Genomics opens U.S. supply chain to genomic sequencing customers through a new manufacturing facility at its San Jose, Calif. headquarters
Element Biosciences Announces Record Sequencer Installation Growth Ahead of Participation in Investor Conferences Element has now received more than 200 cumulative orders of AVITI – the sequencer can provide sequencing on a benchtop for as low as $200 per genome. In just one year, the company’s installed base has grown from more than 20 units to more than 150. Element’s sequencers are now in installed in more than 25 countries.
QIAGEN partners with FBI to develop digital PCR assay for QIAcuity for use in forensics

Cell and Gene Therapy

Solvias to Build Biologics and Cell & Gene Therapy Testing Center in Research Triangle Park

Artificial Intelligence / Machine Learning / Generative AI

Microsoft collaboration launches whole-slide AI model for digital pathology
Epic launches AI validation tool for health systems Will allow healthcare providers to launch and validate artificial intelligence models
ChatGPT for genomes: introducing a CRISPR-designing generative AI
AlphaFold 3 predicts the structure and interactions of all of life’s molecules Published in Nature, we introduce AlphaFold 3, a revolutionary model that can predict the structure and interactions of all life’s molecules with unprecedented accuracy. For the interactions of proteins with other molecule types we see at least a 50% improvement compared with existing prediction methods, and for some important categories of interaction we have doubled prediction accuracy.
Researchers at NVIDIA AI Introduce ‘VILA’: A Vision Language Model that can Reason Among Multiple Images, Learn in Context, and Even Understand Videos

Laboratory Management Systems

Sapio Sciences Unveils Enhanced Molecular Biology Toolkit Sapio ELN 24.5 features multiple improvements, including enhanced CRISPR design with multiple sequence alignment and integration with small molecule research.

Synthetic Biology

Integrated DNA Technologies Invests in New U.S. Synthetic Biology Manufacturing Facility

Miscellaneous

Apple pushes into clinical trials with new FDA nod for Apple Watch
Digital Health Companies Launch The Wonder Woman Collective to Address Critical Gaps in Women’s Healthcare
Home COVID testmaker Cue Health shuts down operations, lays off staff
A whole person view of obesity care: Staying competitive in an evolving market A RockHealth Report
A new genetic test can predict how well Ozempic will work for patients
Integrated Biosciences Joins Illumina Ventures Labs to Design Novel Therapeutics Targeting the Transcriptome
Nikon Instruments Announces Opening of Research Innovation Hub and BioImaging Lab in Lexington, Massachusetts
FDA brings lab tests under federal oversight in bid to improve accuracy and safety
Complex Consequences: FDA’s Final Rule on LDTs and What Laboratories Must Do Now A LinkedIn article by Christine Bump, a regulatory attorney who develops and implements FDA strategies for devices, diagnostics, digital health, and wellness products
Genome Medical Wins Best Overall Genomics Company in 8th Annual MedTech Breakthrough Awards Program
Vizgen Announces Significant Win in Ongoing Patent Litigation Against 10x Genomics and Harvard University

Publications

Scientists discover blood proteins that may give cancer warning 7 years before diagnosis
Benefits and Risks Associated With Statin Therapy for Primary Prevention in Old and Very Old Adults: Real-World Evidence From a Target Trial Emulation Study
A Gram-negative-selective antibiotic that spares the gut microbiome
Antibody-displaying extracellular vesicles for targeted cancer therapy
Pathobiological signatures of dysbiotic lung injury in pediatric patients undergoing stem cell transplantation Describes new sequencing method analyzes lung microbiomes to predict mortality in children following bone marrow transplant
A deep catalogue of protein-coding variation in 983,578 individuals
Integrating single cell expression quantitative trait loci summary statistics to understand complex trait risk genes Demonstrating a new AI algorithm which shows promise in improving autoimmune disease prediction and therapies
Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids
An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wide gene delivery
Particle uptake in cancer cells can predict malignancy and drug resistance using machine learning Study demonstrates novel method combines nano informatics and AI for advances in cancer prediction
Molecular detection of exosomal miRNAs of blood serum for prognosis of colorectal cancer
Ribosomal DNA copy number variation associates with hematological profiles and renal function in the UK Biobank
Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies Healthy lifestyle may offset effects of life-shortening genes by more than 60%
Mammographic density mediates the protective effect of early-life body size on breast cancer risk Study suggests that adiposity in childhood affects the risk of breast cancer by changing breast tissue composition, study suggests
Integrating single cell expression quantitative trait loci summary statistics to understand complex trait risk genes
Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants
Circadian tumor infiltration and function of CD8⁺ T cells dictate immunotherapy efficacy Highlights the importance of the rhythmicity of the immune system for tumor growth
Temporal dynamics of the multi-omic response to endurance exercise training The data and analyses presented in this study highlight the importance of exercise as a health treatment – explores the multi-tissue molecular effects of endurance training. The data is available for download (https://motrpac-data.org/).
The 1+Million Genomes Minimal Dataset for Cancer
Genome Sequencing is Critical for Forecasting Outcomes 1ollowing Congenital Cardiac Surgery
Hacking the immune system could slow ageing — here’s how
Accurate structure prediction of biomolecular interactions with AlphaFold 3 This paper descrobes the AlphaFold 3 model with a substantially updated diffusion-based architecture, which is capable of joint structure prediction of complexes including proteins, nucleic acids, small molecules, ions, and modified residues.
Why is exercise good for you? Scientists are finding answers in our cells Researchers have started to build a picture of the vast maze of cellular and molecular processes that are triggered throughout the body during — and even after — a workout. Some of these processes dial down inflammation, whereas others ramp up cellular repair and maintenance. Exercise also prompts cells to release signaling molecules that carry a frenzy of messages between organs and tissues: from muscle cells to the immune and cardiovascular systems, or from the liver to the brain.

News for the month of April 2024

Funding & IPO

Precision Medicine

Waiting on OIRA for final LDT rule

(Omics) Data Platform / Sequencing / Analysis / Instruments

DNAnexus Starts Restructuring Involving Layoffs, New Hires
DNAnexus and Oracle Collaborate to Advance Precision Health Focus on connecting Oracle’s and DNAnexus’ respective ecosystems. This includes making the DNAnexus platform seamlessly available to global Oracle Cloud Infrastructure, Oracle Health, and Oracle Database customers. In addition, customers will be able to use OCI integration services for their healthcare applications.
UK Biobank and DNAnexus Collaboration Earns Bio-IT World 2024 Innovative Best Practices Global Impact Award for 500,000 Whole Genomes Data Release
Hartwig and Ultima Genomics Collaborate to Reduce Costs for Whole Genome Cancer Profiling, Minimal Residual Disease Testing and Generating Genetic Data at Scale

Single Cell Genomics

Cell and Gene Therapy

Do cutting-edge CAR-T-cell therapies cause cancer? What the data say. As of 25 March, the FDA had received 33 reports of cases of lymphomas (immune-cell cancer) among some 30,000 people who had been treated. It now requires all CAR-T therapies to carry a boxed warning on the drug’s packaging, which states that such cancers have occurred.

Artificial Intelligence / Machine Learning / Generative AI

‘ChatGPT for CRISPR’ creates new gene-editing tools
Moderna partners with OpenAI to accelerate the development of life-saving treatments
How AI improves physician and nurse collaboration
Deep learning tool may advance precision medicine approaches The deep learning-based Lifelong Neural Network for Gene Regulation tool may shed light on how genetic variations influence a patient’s drug response.
PathAI Partners with Google Cloud to Transform Drug Discovery and Precision Medicine Through AI-Powered Pathology

Laboratory Management Systems

Dotmatics announced the launch of Luma^™ Lab Connect, helping R&D laboratories automatically ingest data from instruments or data sources

Miscellaneous

Publications

Refining the impact of genetic evidence on clinical success
Analysis and benchmarking of small and large genomic variants across tandem repeats
Beyond the Human Genome Project: The Age of Complete Human Genome Sequences and Pangenome References
Exosomal mediators in sepsis and inflammatory organ injury: unraveling the role of exosomes in intercellular crosstalk and organ dysfunction
An autoantibody signature predictive for multiple sclerosis Signs of Multiple Sclerosis show up in blood years before symptoms appear
The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy Study identifies novel target for epilepsy treatment
Using AI to improve diagnosis of rare genetic disorders
Stanford Medicine study flags unexpected cells in lung as suspected source of severe COVID
Loci on chromosome 20 interact with rs16969968 to influence cigarettes per day in European ancestry individuals They zeroed in on the single nucleotide polymorphism (SNP), or genetic variant, rs16969968, known as “Mr. Big” because it has been the mostly widely replicated genetic variant associated with smoking behaviors. Mr. Big is located in a gene called CHRNA5F (nicotinic acetylcholine receptor 5) and influences how well nicotine binds to receptors in the brain. People with a certain version of Mr. Big, known as the AA version, are less sensitive to nicotine and have been shown to smoke more.
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits Study discovers over 100 new genomic regions linked to blood pressure
Human skeletal muscle aging atlas First comprehensive atlas sheds new light on processes underlying age-related muscle changes
Feasibility of functional precision medicine for guiding treatment of relapsed or refractory pediatric cancers This functional precision medicine approach combines genomic testing with drug sensitivity testing – feasible to inform treatment decisions for pediatric patients with difficult-to-treat, relapsed/refractory solid and hematologic malignancies.
A digital twin of the infant microbiome to predict neurodevelopmental deficits A new generative AI tool has been developed that models the infant microbiome. The so-called ‘digital twin’ provides new insights into the dynamics of the infant gut microbiota and the impact on neurodevelopment

News for the month of March 2024

Funding & IPO

Surge announces closing of a €7.5 million fundraising round to decrypt the immune system and transform precision medicine Surge, specialized in high-dimensional immune system analysis combined with artificial intelligence
Eli Lilly-backed Zephyr AI secures $111m for precision medicine tech
BeiGene spin-out Pi Health raises $30m to uptick cancer trial enrollment
Assort Health Secures $3.5M for Generative AI Solution for Healthcare Call Centers
Nalu Medical Closes $85M Series E Round Nalu’s neurostimulation system delivers electrical pulses to the nervous system to modulate pain signals before they reach the brain
PreemptiveAI Emerges From Stealth With a Groundbreaking Biomedical Foundation Model For Health Prediction
Siolta Therapeutics Raises $12 Million in Series C Financing for Clinical Development
Milu Health: $4.8 Million Raised To Use AI For Driving Costs Savings In Healthcare
Hippocratic AI banks $53M Launched out of stealth about a year ago, Hippocratic AI launched its first generative AI product and pocketed $53 million in series A funding
Tiny Health, Pioneer of the First At-Home Baby Gut Microbiome Test, Aims to Address the Pediatric Chronic Conditions Crisis – Raises $8.5M in Series A
b.well Connected Health scores $40M to accelerate growth
Matter Neuroscience Raises $26M in Funding – a NYC-based company providing people with personalized insights into their brain chemistry
Alithea Genomics Closes CHF 2.8 Million in Seed Financing Extension Led by Novalis Biotech to launch new RNA sequencing products, expand production capacity, develop new technologies and open US subsidiary

Mergers & Acquisitions

Elevance to buy Kroger’s specialty pharmacy

Precision Medicine

Nucleus Genomics launches to bring whole-genome sequencing to the public us They announced the launch of its DNA analysis product to bring the benefits of personalized medicine to everyone. For a yearly membership fee of $39, members will receive access to new features on Nucleus’ platform, as well as new disease reports and, eventually, reports for traits like height and muscle strength. The 30x WGS kit costs $399.
Fabric Genomics Partners with Intermountain Children’s Health to Enhance Precision Diagnosis of Infants and Children Using Whole Genome Sequencing from Broad Clinical Labs
The Jackson Laboratory and LG AI Research partner to pioneer biomedical advancements
Fabric Genomics Partners with Intermountain Children’s Health to Enhance Precision Diagnosis of Infants and Children Using Whole Genome Sequencing from Broad Clinical Labs

(Omics) Data Platform / Sequencing / Analysis / Instruments

Estonia National Biobank Selects PacBio to Sequence 10,000 Whole Genomes
DNAnexus Adds NVIDIA NIM and CUDA-X Microservices to Precision Health Data Cloud to Accelerate Drug Discovery and Improve Patient Care These microservices are designed to allow researchers and bioinformaticians to easily integrate NVIDIA Parabricks tools into new and existing genomics workflows using the DNAnexus Precision Health Data Cloud to accelerate drug discovery and improve patient care.
Watchmaker Genomics Launches Watchmaker mRNA Library Prep Kits – Featuring a Rapid Workflow and Sensitive mRNA Detection
seqWell Launches First Assay-ready, 384-well Library Preparation Kit to Enable Ultra-high Throughput Plasmid and Synthetic Construct Sequencing
Revvity Introduces New Workflow to Accelerate Newborn Sequencing Research

Genomic / Genetic Testing / CDx

Putting Patients First: Why Congress Must Pass Diagnostic Test Reform An opinion piece by Thierry Bernard (CEO, QIAGEN) and Scott Whitaker (CEO, AdvaMed). This piece highlights the critical role of diagnostics in healthcare decisions and the need for consistent standards and collaborations between private and public sectors to improve patient care. It touches on the impact of the COVID-19 pandemic, which definitely highlighted the relevance of diagnostics in the healthcare value chain. It also proved that patient care makes tremendous progresses when private and public actors come together and act as one. Hospitals are, on average, spending less than 4% of their budget on diagnostics, at very least > 70% of the medical decisions taken for a given patients are impacted by a diagnostic result.
Bayer AG and Thermo Fisher Scientific Inc. collaborate to develop next-generation sequencing (NGS)-based companion diagnostic assays (CDx) together
Labcorp Presents New Research Demonstrating Clinical Impact of Precision Diagnostics in Guiding Biomarker-targeted Therapies for Patients with Epithelial Ovarian Cancer

Artificial Intelligence / Machine Learning / Generative AI

Miscellaneous

WebMD Health Services Announces Strategic Partnership with Verily’s Onduo to Enhance Employee Health and Well-Being
The new era of consumer engagement: Insights from Rock Health’s ninth annual Consumer Adoption Survey Virtual care is now a ubiquitous part of the modern healthcare paradigm
Eli Lilly partners with Amazon Pharmacy for home delivery of its weight loss, diabetes and migraine drugs
Google launches AI-backed search-and-answer tool for doctors
Genseq Selects Sapio LIMS to Power Best-in-Class Next-Generation Sequencing Services
FDA Approves a new indication for use for Wegovy (semaglutide) to Reduce Risk of Serious Heart Problems Specifically in Adults with Obesity or Overweight
Biden Signs Executive Order to Expand Research on Women’s Health
Lancet Menopause Series Wants to Change How Society Views ‘The Change’
Mark Cuban’s Cost Plus Drugs will begin manufacturing its own medications this week
CVS and Walgreens Will Begin Selling Abortion Pills This Month The pill mifepristone will be available with a prescription at pharmacy counters in a few states to start

Publications

Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy Study used FTIR microspectroscopy combined with a machine learning algorithm and was able to identify a single lung cancer cell in a sample of blood.
Comprehensive whole-genome sequence analysis provides insights into the genomic architecture of cerebral palsy Whole-genome sequencing was conducted in 327 children with CP, including their biological parents, and compared it to three independent clinical cohorts as well as two pediatric control cohorts, to identify whether genetic variants may be involved in CP. The seven-year study found that more than one in ten children (11.3 percent) had a genetic variant or likely genetic variant for their CP, and 17.7 percent of children had variants of uncertain significance that may be linked with CP after further research. Many of the variants also overlapped with other neurodevelopmental conditions, including autism spectrum disorder (ASD), which is highly prevalent in children with CP.
The effects of genetic and modifiable risk factors on brain regions vulnerable to aging and disease Study determined the genetic influences and the impact of modifiable risk factors (MRFs) on a brain network vulnerable to aging, schizophrenia, and Alzheimer’s disease in approximately 40,000 United Kingdom (UK) Biobank participants. Included data from 39,676 participants who underwent structural T1-weighted brain scans.
Key variants via the Alzheimer’s Disease Sequencing Project whole genome sequence data Seventeen variants were significantly associated with AD within five genomic regions implicating the genes OARD1/NFYA/TREML1, JAZF1, FERMT2, and SLC24A4. KAT8 was implicated by both single variant and rare variant aggregate analyses. The analyses were restricted to variants within 100 kb of 83 previously identified GWAS lead variants.
Population-level comparisons of gene regulatory networks modeled on high-throughput single-cell transcriptomics data They present SCORPION, a tool that uses a message-passing algorithm to reconstruct comparable gene regulatory networks from single-cell/nuclei RNA-sequencing data that are suitable for population-level comparisons by leveraging the same baseline priors.
The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank Using data from four studies that connect genetic variants to lifespan, scientists have developed 11 different polygenic longevity scores (PLS) that predict both long life and resilience to some age-related conditions such as Alzheimer’s disease and heart disease. The researchers, led by scientists from the Translational Genomics Research Institute (TGen), part of City of Hope, constructed the scores and tested them with genomic data collected by UK BioBank, which represents around 480,000 people from the United Kingdom who were between the ages of 40 and 69 at the time the BioBank study was underway.
Multi-ancestry polygenic mechanisms of type 2 diabetes Genetic study identified various genetic clusters involved in a broad range of biological mechanisms that may help explain ancestry-associated differences in type 2 diabetes clinical presentations.
Patient derived tumoroids of high grade neuroendocrine neoplasms for more personalized therapies
For childhood cancer survivors, inherited genetic factors influence risk of cancers later in life
Systemic proteome adaptions to 7-day complete caloric restriction in humans Researchers followed 12 healthy volunteers taking part in a seven-day water-only fast. The volunteers were monitored closely on a daily basis to record changes in the levels of around 3,000 proteins in their blood before, during, and after the fast. As expected, the researchers observed the body switching energy sources—from glucose to fat stored in the body—within the first two or three days of fasting. The volunteers lost an average of 5.7 kg of both fat mass and lean mass. After three days of eating after fasting, the weight stayed off—the loss of lean was almost completely reversed, but the fat mass stayed off.
fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles

News for the month of February 2024

Funding & IPO

BlossomHill Therapeutics Closes $100 Million Series B Financing – a biotechnology company that focuses on the design and development of small molecule medicines for treating cancer and autoimmune diseases. BlossomHill Therapeutics was founded by Jean Cui, a former Pfizer chemist whose last company was sold to Bristol Myers Squibb for $4 billion.
Interdisciplinary project aims to decode human kinome in brain function and disease – Receives CZI Grant
BioAge secures $170m for obesity therapeutics development
Invitae files for Chapter 11 protection, pursues sale process
$1.9M NIH grant to support research on impacts of the microbiome on human health
Nanostring Initiates Voluntary Chapter 11 Restructuring Proceedings with Additional $40 Million in Financing Secured from Existing Noteholders to Facilitate Process Continuing to Serve Life Sciences Researchers Worldwide NanoString Takes Steps to Restructure Its Business and Protect Its Mission to Map the Universe of Biology
NanoString files for bankruptcy, explores potential sale amid patent battle with 10x Genomics

Precision Medicine

Genomic data in the All of Us Research Program Landmark paper of the All of Us Research Program demonstrating the most diverse biobank to date with half of the genomes from non-Europeans. All of Us identified more than 1 billion genetic variants, including more than 275 million previously unreported genetic variants, more than 3.9 million of which had coding consequences. Leveraging linkage between genomic data and the longitudinal electronic health record, we evaluated 3,724 genetic variants associated with 117 diseases and found high replication rates across both participants of European ancestry and participants of African ancestry.
‘All of Us’ reports half of the genomes it has sequenced are from non-Europeans

(Omics) Data Platform / Sequencing / Analysis / Instruments

QIAGEN launches AI-derived biomedical knowledge base to accelerate data-driven drug discovery QIAGEN Biomedical KB-AI contains over 640 million biomedical relationships, including gene, disease, and drug causal relationships, to aid in data-driven drug discovery
DNAnexus and LORENZ Partner To Enable Collaborative Regulatory Submission Validation and Scientific Review in the Cloud
Golden Helix is Launching VSPGx, a pharmacogenomics solution for hospitals and testing labs
Clinical utility of polygenic risk scores for embryo selection: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG)
Ultima Announces UG 100^™ and Reveals Disruptive Cost and Accuracy Profile to Enable the Era of the $100 Genome and Beyond (AGBT 2024)
Complete Genomics and seqWell Announce Co-development Partnership at AGBT (AGBT 2024)
Illumina Reports Financial Results for Fourth Quarter and Fiscal Year 2023
PacBio Announces HiFi Prep Kit 96 and HiFi Plex Prep Kit 96 for Long-Read Sequencing Applications at Scale (AGBT 2024)
Integrated DNA Technologies and Element Biosciences Accelerate Next Generation Sequencing Workflows for Element’s AVITI™ System (AGBT 2024)
Volta Labs and Watchmaker Genomics Partner to Simplify and Optimize NGS Library Prep (AGBT 2024)
Scale Biosciences Unveils Platform for Dramatic Scaling of Single-Cell Experiments and Announces Partnerships to Drive Ease of Use and Enable New Biological Insights (AGBT 2024)
Element to Present Data on New Products and Multi-Omics Capabilities (AGBT 2024)
Element Biosciences and DNAnexus® Announce Collaboration to Advance Multi-Omics Analysis (AGBT 2024) The collaboration allows customers to stream data from Element’s AVITI™ System directly to their DNAnexus account.

Genomic / Genetic Testing / CDx

Gattaca Genomics Leads the Way in Revolutionizing Fertility with Artificial Intelligence for Full Genome Analysis, Including Preimplantation Genetic Testing and Genetic Counseling

Spatial Genomics / Single Cell Genomics

CRISPR/Genome Editing

Turbocharging CRISPR to Understand How the Immune System Fights Cancer
New CRISPR Gene-Editing Treatment Approved In Europe For Inherited Blood Disorders
CRISPRed Pigs: Precision Porcine Gene Editing Combats PRRS Virus Threat Scientists are seeking FDA approval to bring the edited pigs to market.

Miscellaneous

Publications

An atlas of epithelial cell states and plasticity in lung adenocarcinoma
Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease
Effect of Behavioral Health Disorders on Surgical Outcomes in Cancer Patients
Genomic evolution shapes prostate cancer disease type
‘All of Us’ Research Program Identifies 275 Million New Genetic Variants Researchers have discovered more than 275 million previously unreported genetic variants, identified from data shared by nearly 250,000 participants of the National Institutes of Health’s All of Us Research Program. Half of the genomic data are from participants of non-European genetic ancestry. The unexplored cache of variants provides researchers new pathways to better understand the genetic influences on health and disease, especially in communities that have been left out of research in the past. The findings are detailed in Nature, alongside three other articles in Nature journals.
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation
Spatial functional mapping of hypoxia inducible factor heterodimerisation and immune checkpoint regulators in clear cell renal cell carcinoma Scientists have developed a new AI tool that maps the function of proteins in a cancerous tumor (clear cell renal cell carcinoma (ccRCC)), enabling clinicians to decide how to target treatment in a more precise way.
Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever The study analyzed Lassa fever susceptibility and fatal outcomes in 533 cases of Lassa fever and 1,986 population controls recruited over a 7 year period in Nigeria and Sierra Leone. They detected genome-wide significant variant associations with Lassa fever fatal outcomes near GRM7 and LIF in the Nigerian cohort.
Stanford Medicine-led study shows why women are at greater risk of autoimmune disease

News for the month of January 2024

Funding and IPO

SmartLabs Announces $48 Million Series C Funding to Advance Its Laboratory Infrastructure and Resourcing Solutions

Precision Medicine

Illusory generalizability of clinical prediction models The quest for personalized medicine, a medical approach in which practitioners use a patient’s unique genetic profile to tailor individual treatment, has emerged as a critical goal in the health care sector. But a new Yale-led study shows that the mathematical models currently available to predict treatments have limited effectiveness.

(Omics) Data Platform / Sequencing / Analysis / Instruments

DNAnexus and Intelliseq Combine Efforts to Add Automated Genomic Variant Interpretation and Clinical Reporting Capabilities to Precision Health Data Cloud
Terra is Now Generally Available on Microsoft Azure The Broad Institute of MIT and Harvard has made Terra generally available on Microsoft Azure. Terra is Broad’s flagship biomedical data platform, co-developed by Broad, Microsoft, and Verily. The open-source platform is used by over 65,000 individuals globally for biomedical data analysis, secure data sharing, and cross-enterprise data science collaborations. Through Terra, researchers can gain access to genomics and other data modalities used for biomedical research, as well as run state-of-the-art workflows developed by Broad and wider bioinformatics community.
Ultima Genomics launching high-end DNA sequencers that can read genome for $100

Miscellaneous

Publications

Myeloid and lymphoid expression of C9orf72 regulates IL-17A signaling in mice This new study uncovers why gene is believed to be responsible for ALS and dementia
Variant in the synaptonemal complex protein SYCE2 associates with pregnancy loss through effect on recombination Over 114 thousand women from Iceland, Denmark, UK, USA and Finland who have experienced pregnancy loss participated in a genome-wide association study, were tested for50 million sequence variants. A low frequency missense variant in the SYCE2 gene was found to increase the risk of pregnancy loss by 22%.
Inceptor counteracts insulin signalling in β-cells to control glycaemic Research targeting the insulin-inhibitory receptor, called “inceptor,” unveils promising avenues for beta cell protection, offering hope for causal diabetes therapy. A novel study in mice with diet-induced obesity demonstrates that the knock-out of inceptor enhances glucose regulation, prompting its further exploration as a drug target for type 2 diabetes treatment.
Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme The study, led by Genomics England, NHS England, Queen Mary University of London, Guy’s and St Thomas’ NHS Foundation Trust and the University of Westminster, analyzed data covering over 30 types of solid tumors collected from more than 13,000 participants with cancer in the 100,000 Genomes Project. By looking at the genomic data alongside routine clinical data collected from participants over a 5-year period, such as hospital visits and the type of treatment they received, scientists were able to find specific genetic changes in the cancer associated with better or worse survival rates and improved patient outcomes.
A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma
Adjusting for genetic confounders in transcriptome-wide association studies improves discovery of risk genes of complex traits A new statistical tool developed by researchers at the University of Chicago improves the ability to find genetic variants that cause disease. The tool combines data from genome wide association studies (GWAS) and predictions of genetic expression to limit the number of false positives and more accurately identify causal genes and variants for a disease.
Scalable, accessible and reproducible reference genome assembly and evaluation in Galaxy
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

Following are archived industry news

COVID-19 / SARS-CoV-2

Collated COVID-19/SARS-CoV-2 Information

Industry News – 2024

News for the month of December 2024

Funding and & IPO

Mergers & Acquisitions

(Omics) Data Platform / Sequencing / Analysis / Instruments

Genomic / Genetic Testing / CDx

Laboratory Management/Informatics Platforms

Digital Health

Artificial Intelligence / Machine Learning / ChatGPT

Miscellaneous

Publications

News for the month of November 2024

Funding & IPO

Mergers & Acquisitions

Precision Medicine

(Omics) Data Platform / Sequencing / Analysis / Instruments

Genomic / Genetic Testing / CDx

Artificial Intelligence / Machine Learning / LLM / ChatGPT / GenAI

Metagenomics

CRISPR/Genome Editing

Miscellaneous

Publications

News for the month of October 2024

Funding & IPO

Mergers & Acquisitions

Precision Medicine

(Omics) Data Platform / Sequencing / Analysis / Instruments

Genomic / Genetic Testing / CDx

Pharmacogenetics (PGx)

Laboratory Management/Informatics Platforms

RWD / RWE

Artificial Intelligence / Machine Learning / LLM / ChatGPT

Miscellaneous

Publications

News for the month of September 2024

Funding & IPO

Mergers & Acquisitions

Precision Medicine

Genomic / Genetic Testing / CDx

(Omics) Data Platform / Sequencing / Analysis / Instruments

Spatial Genomics / Single Cell Genomics

Data Platforms / Laboratory Management Systems

Artificial Intelligence / Machine Learning / LLM / ChatGPT

RWD / RWE

Miscellaneous

Publications

News for the month of August 2024

Funding & IPO

Mergers & Acquisitions

Precision Medicine

(Omics) Data Platform / Sequencing / Analysis / Instruments

Spatial Omics / Single-cell Genomics

CRISPR / Genome Editing

Laboratory/Scientific Management Systems

Miscellaneous

Artificial Intelligence / Machine Learning / ChatGPT

Publications

News for the month of July 2024

Funding & IPO

Mergers & Acquisitions

Precision Medicine

(Omics) Data Platform / Sequencing / Analysis / Instruments

Genomic / Genetic Testing / CDx

Artificial Intelligence / Machine Learning / ChatGPT

Miscellaneous

Publications

News for the month of June 2024

Funding and IPO

Precision Medicine

(Omics) Data Platform / Sequencing / Analysis / Instruments

Artificial Intelligence / Machine Learning / ChatGPT

Spatial Omics / Single-cell Genomics

CRISPR/Genome Editing

Miscellaneous

Publications

News for the month of May 2024

Funding & IPO

Precision Medicine

(Omics) Data Platform / Sequencing / Analysis / Instruments

Cell and Gene Therapy